Diethyl Oxalate → HCID 25241804, compound

HRID 2421911Notes

Reaction equation

HRID 2421911 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])[C:3]=1[C:17]#[N:18].[C:19](OCC)(=[O:25])[C:20](OCC)=[O:21]>>[CH3:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:4]1[CH:5]=[CH:6][C:7]2[NH:8][C:20](=[O:21])[C:19](=[O:25])[NH:1][C:2]=2[C:3]=1[C:17]#[N:18]

Participants

3

Reactant 2

HCID 7268Diethyl OxalateHCID 25241803HCID 25241803, compound

Product 1

HCID 25241804HCID 25241804, compound

Procedure

This crude 3,4-diamino-2′methoxy-biphenyl-2-carbonitrile was stirred in diethyl oxalate (5 mL) at reflux for 5 h. The solution was concentrated in vacuo to give 320 mg (quantitative yield) of the title compound as an insoluble solid. MS (ES) [m+H] calc'd for C16H11N3O3, 294; found 294.

Workup

  1. temperatureat reflux for 5 h
  2. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-1f0caf7bd06a4302aa89fa609330f08a
Source dataset
uspto-grants-2011_06
Patent number
US07960384B2

Reaction notes

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