1-(3-Chlorophenyl)piperazine → HCID 58834857, compound

HRID 2421927Notes

Reaction equation

HRID 2421927 reaction equation
C1(P(=[N:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2/[CH:27]=[CH:28]/[C:29]([O:31][CH3:32])=[O:30])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]=[C:41]=O)=[C:36]([CH3:43])[CH:35]=1.[Cl:44][C:45]1[CH:46]=[C:47]([N:51]2[CH2:56][CH2:55][NH:54][CH2:53][CH2:52]2)[CH:48]=[CH:49][CH:50]=1>>[Cl:44][C:45]1[CH:46]=[C:47]([N:51]2[CH2:56][CH2:55][N:54]([C:41]3[N:40]([C:37]4[CH:38]=[CH:39][C:34]([Cl:33])=[CH:35][C:36]=4[CH3:43])[CH:27]([CH2:28][C:29]([O:31][CH3:32])=[O:30])[C:22]4[C:21](=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:20]=3)[CH2:53][CH2:52]2)[CH:48]=[CH:49][CH:50]=1

Participants

4

Reactant 3

HCID 13551-(3-Chlorophenyl)piperazineHCID 1421574-Chloro-2-methylphenyl isocyanateHCID 11826263HCID 11826263, compound

Product 1

HCID 58834857HCID 58834857, compound

Procedure

Starting with 150 mg (0.34 mmol) of the iminophosphorane from Example 3A, 60 mg (0.36 mmol) of 4-chloro-2-methylphenyl isocyanate and 67 mg (0.34 mmol) of N-(3-chlorophenyl)piperazine, the general procedure [E] and chromatographic purification (method 2) give 97 mg (46% of theory) of product.

Workup

  1. customthe general procedure [E] and chromatographic purification (method 2)
  2. customgive 97 mg (46% of theory) of product

Sources & evidence

ORD record
ord-6eb7615f307846589e8ff86609869e32
Source dataset
uspto-grants-2011_06
Patent number
US07960387B2

Reaction notes

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