HCID 67242996, compound → HCID 178462963, compound

HRID 2422067Notes

Reaction equation

HRID 2422067 reaction equation
Cl[C:2]1[C:3](=[O:17])[N:4]([CH2:15][CH3:16])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH:18]1[CH:22]=[C:21]([CH2:23][CH2:24][NH2:25])[N:20]=[CH:19]1>>[CH2:15]([N:4]1[C:3](=[O:17])[C:2]([NH:25][CH2:24][CH2:23][C:21]2[N:20]=[CH:19][NH:18][CH:22]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13])[CH3:16]

Participants

3

Reactant 2

HCID 67242996HCID 67242996, compoundHCID 178419017HCID 178419017, compound

Product 1

HCID 178462963HCID 178462963, compound

Procedure

The title compound was prepared from 4-chloro-2-ethyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 2-(1H-imidazol-4-yl)ethanamine in a similar manner as described for Example 1. 1H NMR (500 MHz, CD3OD): δ 7.54-7.42 (m, 6H), 6.51-6.48 (m, 1H), 3.71 (q, 2H), 3.14 (t, 2H), 2.55 (t, 2H), 1.36 (t, 3H); 13C NMR (125 MHz, CD3OD): δ 159.9, 137.3, 136.1, 132.9, 132.3, 130.6, 129.7, 126.9, 117.2, 107.2, 44.6, 36.0, 27.8, 14.0; Mass Spectrum: M+H+ 347.

Sources & evidence

ORD record
ord-116bfe68031d44baade59fbd4e955a0d
Source dataset
uspto-grants-2011_06
Patent number
US07960380B2

Reaction notes

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