Homoveratrylamine → HCID 67244091, compound

HRID 2422122Notes

Reaction equation

[C:1]([N:5]1[C:9](=[O:10])[C:8](Cl)=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:6]1(=[O:19])=[O:18])([CH3:4])([CH3:3])C.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][CH2:31][NH2:32])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][CH2:31][NH:32][C:8]2[C:9](=[O:10])[N:5]([CH:1]([CH3:3])[CH3:4])[S:6](=[O:18])(=[O:19])[C:7]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

Reactant 2

HCID 8421Homoveratrylamine

HCID 672426272-tert-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 67244091HCID 67244091, compound

Procedure

The title compound was prepared from 2-tert-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide and [2-(3,4-dimethoxyphenyl)ethyl]amine in a similar manner as described for Example 24. 1H NMR (500 MHz CDCl3): δ 7.58-7.52 (m, 2H), 7.50-7.46 (m, 3H), 6.76 (d, 1H), 6.46 (dd, 1H), 6.36 (d, 1H), 5.40 (t, 1H), 4.41 (sept, 1H), 3.86 (s, 3H), 3.82 (s, 3H), 3.13 (q, 2H), 2.57 (t, 2H), 1.59 (d, 6H); 13C NMR (125 MHz, CDCl3): δ 158.7, 149.3, 148.1, 135.4, 131.7, 130.0, 129.9, 128.8, 125.4, 120.8, 111.8, 111.7, 107.2, 56.1, 47.8, 45.3, 35.6, 20.3; Mass Spectrum M+H+ 431

Sources & evidence

ORD record: ord-1ef72a079ec44d3a95ab16b98a2de0f6
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960380B2

Reaction notes

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