HCID 58248072, compound → HCID 24762209, compound

HRID 2422176Notes

Reaction equation

HRID 2422176 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([S:10][C:11]2[N:12]=[C:13]([NH:22][C@H:23]([CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:24][OH:25])[C:14]3[S:19][C:18]([O:20]C)=[N:17][C:15]=3[N:16]=2)[CH3:9])=[N:6][CH:7]=1>[Cl-].[Na+].O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([S:10][C:11]2[N:12]=[C:13]([NH:22][C@@H:23]([CH2:24][OH:25])[CH2:26][CH:27]([CH3:28])[CH3:29])[C:14]3[S:19][C:18](=[O:20])[NH:17][C:15]=3[N:16]=2)[CH3:9])=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 58248072HCID 58248072, compound

Product 1

HCID 24762209HCID 24762209, compound

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent

Conditions

Temperature
50 °C

Procedure

The title compound was prepared from (2R)-2-[(5-{[(1S)-1-(5-chloropyridin-2-yl)ethyl]thio}-2-methoxy[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol from the previous step using General method D except that the reaction mixture was stirred at 50° C. for 2.5 h and then at room temperature over night. After complete reaction the reaction mixture was diluted with Brine and extracted with DCM (three times). The combined organic extracts were dried over sodium sulphate and concentrated in vacuo.

Workup

  1. waitat room temperature over night
  2. customAfter complete reaction the reaction mixture
  3. extractionextracted with DCM (three times)
  4. dry with materialThe combined organic extracts were dried over sodium sulphate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1622539e9f7c4678b7ac3e4adb3413ae
Source dataset
uspto-grants-2011_06
Patent number
US07960395B2

Reaction notes

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