HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 242236Generated: October 31, 2026
Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine
https://huagongshe.com/reaction/242236
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-6-piperidin-1-ylpyrimidine | HCID 597870 | — |
Reaction Steps
A mixture of 10.0 g (67.1 mmol) 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) piperidine in 100 ml water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08653111B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-305f8fbcba8240e6bc70a43cf87b4385 |
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| Source note | uspto-grants-2014_02 |
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