Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine

HRID 242236Notes

Reaction equation

HRID 242236 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[CH:7]=[C:2]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=[CH:4][N:5]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 5978704-Chloro-6-piperidin-1-ylpyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
115 °C

Procedure

A mixture of 10.0 g (67.1 mmol) 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) piperidine in 100 ml water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried in vacuo.

Workup

  1. temperatureAfter cooling to RT
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-305f8fbcba8240e6bc70a43cf87b4385
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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