Hydrochloric Acid → HCID 57475117, compound

HRID 2422390Notes

Reaction equation

HRID 2422390 reaction equation
Cl.[C:2]1([C:8]2([N:18]3[CH2:21][CH2:20][CH2:19]3)[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CC(C)=O>[N:18]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)[CH2:19][CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57475116HCID 57475116, compound

Product 1

HCID 57475117HCID 57475117, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6 N Hydrochloric acid (2 ml) was added to a solution of 1-(8-phenyl-1,4-dioxaspiro[4,5]dec-8-yl)azetidine (370 mg, 1.3 mmol) in acetone (30 ml) and the mixture was stirred overnight at room temperature. The pH was adjusted to 10 by the addition of 5 N sodium hydroxide solution and the aqueous phase was extracted with dichloromethane (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated to small volume under vacuum. Yield: 274 mg (92%), white solid. Melting point: not determinable

Workup

  1. extractionthe aqueous phase was extracted with dichloromethane (3×20 ml)
  2. dry with materialThe combined organic phases were dried with sodium sulfate
  3. concentrationconcentrated to small volume under vacuum

Sources & evidence

ORD record
ord-5017befa6c1b4181b1ee791dfcce5863
Source dataset
uspto-grants-2011_06
Patent number
US07960404B2

Reaction notes

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