反应详情

53.0 g (2.7 mmol) 4-(6-chloropyrimidin-4-yl)morpholine are initially introduced into 260 ml ethanol. 132.9 g (2.7 mol) hydrazine hydrate are added and the mixture is stirred under reflux for 16 h. Thereafter, it is cooled to RT and approx. half of the solvent is removed by distillation. The mixture is cooled to 0° C. and the solid formed is filtered off It is rinsed with cold ethanol and the solid is dried first in air and then in vacuo.

1. temperatureunder reflux for 16 h
2. customis removed by distillation
3. temperatureThe mixture is cooled to 0° C.
4. customthe solid formed
5. filtrationis filtered off It
6. washis rinsed with cold ethanol
7. customthe solid is dried first in air