反应详情

1.0 g (7.8 mmol) 2-chloro-5-methylpyridine are stirred under reflux in 5.7 ml (5.9 g, 117.6 mmol) hydrazine hydrate for 12 h. 10 ml ethylene glycol monoethyl ether are added to the cooled reaction mixture and the solvent is then removed completely on a rotary evaporator. This working step is repeated twice, methylene chloride is then added to the residue, the precipitate is filtered off, the filtrate is concentrated in vacuo and the residue is dried in vacuo.

1. customthe solvent is then removed completely on a rotary evaporator
2. additionmethylene chloride is then added to the residue
3. filtrationthe precipitate is filtered off
4. concentrationthe filtrate is concentrated in vacuo
5. customthe residue is dried in vacuo