反应详情

3.3 g (35.3 mmol) 1H-imidazole-4-carbonitrile [Matthews et al., J. Org. Chem. 1986, 51, 3228-3231] are initially introduced into 13.2 ml (11.5 g, 35.3 mmol) 21% strength sodium ethylate solution in ethanol and 4.3 ml (6.5 g, 38.9 mmol) ethyl bromoacetate are added. The reaction mixture is stirred at RT for 16 h. For working up, the solid which has precipitated out is filtered off, the residue on the filter is washed with ethanol and the filtrate is concentrated in vacuo. Diisopropyl ether is added to the residue, the mixture is filtered again, the filtrate is concentrated again on a rotary evaporator and the residue is dried in vacuo.

1. additionare added
2. customthe solid which has precipitated out
3. filtrationis filtered off
4. washthe residue on the filter is washed with ethanol
5. concentrationthe filtrate is concentrated in vacuo
6. additionDiisopropyl ether is added to the residue
7. filtrationthe mixture is filtered again
8. concentrationthe filtrate is concentrated again on a rotary evaporator
9. customthe residue is dried in vacuo