HRID2422563

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Na+].[Na+]

HCID62649

Disodium sulfate decahydrate

H20Na2O14S

HCID21225700

未命名化合物

结构：CC[C@](O)(c1cn(Cc2ccc3c(-c4ccc(F)cc4)cc(C(C)=O)nc3c2)nn1)C(F)(F)F

HCID66790923

未命名化合物

PRODUCTS

生成物

HCID66791197

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID180

Acetone

C3H6O

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of (S)-1-[4-(4-fluorophenyl)-7-({4-[1-hydroxy-1-(trifluoromethyl)propyl]-1H-1,2,3-triazol-1-yl}methyl)quinolin-2-yl]ethanone (100 mg, 0.21 mmol) in dichloromethane (5 mL) at −78° C. was added diisobutylaluminum hydride (79 μL, 0.44 mmole). The solution was stirred 20 minutes after which a few drops of acetone were added. The reaction was warmed up to rt and sodium sulfate decahydrate (205 mg, 0.63 mmol) was added. After stirring for 30 minutes the mixture was filtered on celite and concentrated. Purification on silica gel (eluting with acetone/dichloromethane, 3:7) gave the title compound. MS (+ESI): 475 (M+H)+.

WORKUP

后处理

additionwere added
filtrationwas filtered on celite and
concentrationconcentrated
customPurification on silica gel (eluting with acetone/dichloromethane, 3:7)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-489769b6419740d0a2c5276f5aaab99d
来源数据集: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07960409B2
来源说明: uspto-grants-2011_06

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([CH2:18][N:19]4[CH:23]=[C:22]([C@:24]([OH:31])([C:27]([F:30])([F:29])[F:28])[CH2:25][CH3:26])[N:21]=[N:20]4)=[CH:15][CH:16]=3)[N:11]=[C:10]([C:32](=[O:34])[CH3:33])[CH:9]=2)=[CH:4][CH:3]=1.[H-].C([Al+]CC(C)C)C(C)C.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>ClCCl.CC(C)=O>[F:30][C:27]([F:28])([F:29])[C@:24]([C:22]1[N:21]=[N:20][N:19]([CH2:18][C:14]2[CH:13]=[C:12]3[C:17]([C:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[CH:9][C:10]([CH:32]([OH:34])[CH3:33])=[N:11]3)=[CH:16][CH:15]=2)[CH:23]=1)([OH:31])[CH2:25][CH3:26]