Methylamine → 3-Methyl-2-[4-(3-pyrrolidin-1-ylpropoxy)-phenyl]pyrido[2,3-d]-pyrimidin-4(3H)-one

HRID 2422592Notes

Reaction equation

HRID 2422592 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][NH2:12].[N:13]1([CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH3:11][N:12]1[C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[N:10][C:2]=2[N:1]=[C:26]1[C:25]1[CH:28]=[CH:29][C:22]([O:21][CH2:20][CH2:19][CH2:18][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 729302-Aminonicotinic acidHCID 116515734-(3-Pyrrolidin-1-ylpropoxy)benzaldehyde

Product 1

HCID 116175273-Methyl-2-[4-(3-pyrrolidin-1-ylpropoxy)-phenyl]pyrido[2,3-d]-pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-aminonicotinic acid, methylamine and 4-(3-pyrrolidin-1-ylpropoxy)benzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-84205448d9b640479088b0f16c6234f1
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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