Methylamine → 2-[4-(1-Cyclobutyl-4-piperidinyloxy)phenyl]-3-methylpyrido[2,3-d]-pyrimidin-4(3H)-one

HRID 2422594Notes

Reaction equation

HRID 2422594 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][NH2:12].[CH:13]1([N:17]2[CH2:22][CH2:21][CH:20]([O:23][C:24]3[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14]1>>[CH:13]1([N:17]2[CH2:22][CH2:21][CH:20]([O:23][C:24]3[CH:31]=[CH:30][C:27]([C:28]4[N:12]([CH3:11])[C:4](=[O:6])[C:3]5[CH:7]=[CH:8][CH:9]=[N:10][C:2]=5[N:1]=4)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 729302-Aminonicotinic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

Product 1

HCID 116252932-[4-(1-Cyclobutyl-4-piperidinyloxy)phenyl]-3-methylpyrido[2,3-d]-pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-aminonicotinic acid, methylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde. The obtained compound was recrystallized from diethyl ether to give a colorless solid (m.p. 146.0-150.0° C.).

Workup

  1. customThe entitled compound was obtained
  2. customThe obtained compound was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-4b341d4ba8d44b6881488bd26f6acc32
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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