2-Methoxyethylamine → 2-[4-(1-Cyclobutyl-4-piperidinyloxy)phenyl]-3-(2-methoxyethyl)pyrido[2,3-d]pyrimidin-4(3H)-one

HRID 2422595Notes

Reaction equation

HRID 2422595 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][O:12][CH2:13][CH2:14][NH2:15].[CH:16]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17]1>>[CH:16]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([C:31]4[N:15]([CH2:14][CH2:13][O:12][CH3:11])[C:4](=[O:6])[C:3]5[CH:7]=[CH:8][CH:9]=[N:10][C:2]=5[N:1]=4)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 729302-Aminonicotinic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

Product 1

HCID 115393312-[4-(1-Cyclobutyl-4-piperidinyloxy)phenyl]-3-(2-methoxyethyl)pyrido[2,3-d]pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-aminonicotinic acid, 2-methoxyethylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-caaff30d4ce844ddae869166023843a7
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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