Methylamine → 7-Bromo-2-{4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-one

HRID 2422597Notes

Reaction equation

HRID 2422597 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:12][NH2:13].[CH:14]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[C:28]([O:34][CH3:35])[CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16][CH2:15]1>>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[C:9](=[O:11])[N:13]([CH3:12])[C:30]([C:29]3[CH:32]=[CH:33][C:26]([O:25][CH:22]4[CH2:23][CH2:24][N:19]([CH:14]5[CH2:18][CH2:17][CH2:16][CH2:15]5)[CH2:20][CH2:21]4)=[CH:27][C:28]=3[O:34][CH3:35])=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 497615813-Amino-5-bromopyridine-2-carboxylic acidHCID 860848044-[(1-Cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde

Product 1

HCID 115118617-Bromo-2-{4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 3-amino-5-bromopyridine-2-carboxylic acid, methylamine and 4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-9a900380dc1b4174ad0b6812da710ecc
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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