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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2422598Generated: October 26, 2026

Methylamine → 7-Bromo-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-one

https://huagongshe.com/reaction/2422598

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylamineHCID 6329—
Reactant3-Amino-5-bromopyridine-2-carboxylic acidHCID 49761581—
Reactant4-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehydeHCID 86624462—
Product7-Bromo-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-oneHCID 11677714—

Reaction Steps

The entitled compound was obtained according to the method of Example 15 but starting from 3-amino-5-bromopyridine-2-carboxylic acid, methylamine and 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960394B2
Source datasetuspto-grants-2011_06
ORD IDord-98d2350945c24a1982ebc2f68e0c2368
Source noteuspto-grants-2011_06