Methylamine → 7-Bromo-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-one

HRID 2422598Notes

Reaction equation

HRID 2422598 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:12][NH2:13].[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[C:27]([O:33][CH3:34])[CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1>>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[C:9](=[O:11])[N:13]([CH3:12])[C:29]([C:28]3[CH:31]=[CH:32][C:25]([O:24][CH:21]4[CH2:22][CH2:23][N:18]([CH:14]5[CH2:17][CH2:16][CH2:15]5)[CH2:19][CH2:20]4)=[CH:26][C:27]=3[O:33][CH3:34])=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 497615813-Amino-5-bromopyridine-2-carboxylic acidHCID 866244624-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde

Product 1

HCID 116777147-Bromo-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxyphenyl}-3-methylpyrido[3,2-d]pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 3-amino-5-bromopyridine-2-carboxylic acid, methylamine and 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-98d2350945c24a1982ebc2f68e0c2368
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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