Methylamine → 2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-fluoro-3-methylquinazolin-4(3H)-one

HRID 2422612Notes

Reaction equation

HRID 2422612 reaction equation
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][NH2:13].[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[C:27](OC)[CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1>>[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([C:29]4[N:13]([CH3:12])[C:4](=[O:6])[C:3]5[C:2](=[C:10]([F:11])[CH:9]=[CH:8][CH:7]=5)[N:1]=4)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 5864082-Amino-3-fluorobenzoic acidHCID 866244624-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde

Product 1

HCID 115023812-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-fluoro-3-methylquinazolin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-amino-3-fluorobenzoic acid, methylamine and 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-7573dae41ad0491e93c30a61663a4698
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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