HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-Amino-2-methoxypyridine-4-carboxylic acid | HCID 2762507 | — |
| Reactant | 4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde | HCID 86624461 | — |
| Product | 2-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one | HCID 11633143 | — |
Reaction Steps
The entitled compound was obtained according to the method of Example 15 but starting from 5-amino-2-methoxyisonicotinic acid, methylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde. The resulting compound was recrystallized from ethyl acetate-heptane to give a colorless tabular crystal (m.p. 146.5-148.0° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960394B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-7a99071d993e407396c0e607bcec47e9 |
| Source note | uspto-grants-2011_06 |