Methylamine → HCID 11647733, compound

HRID 2422663Notes

Reaction equation

HRID 2422663 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][NH2:12].[CH3:13][O:14][C:15]1[CH:22]=[C:21]([OH:23])[CH:20]=[CH:19][C:16]=1[CH:17]=O.O[CH:25]1[CH2:30][CH2:29][N:28]([C:31](OC(C)(C)C)=O)[CH2:27][CH2:26]1.[C:38]1(=O)C[CH2:41][CH2:40][CH2:39]1>>[CH:31]1([N:28]2[CH2:27][CH2:26][CH:25]([O:23][C:21]3[CH:20]=[CH:19][C:16]([C:17]4[N:12]([CH3:11])[C:4](=[O:6])[C:3]5[CH:7]=[CH:8][CH:9]=[N:10][C:2]=5[N:1]=4)=[C:15]([O:14][CH3:13])[CH:22]=3)[CH2:30][CH2:29]2)[CH2:41][CH2:40][CH2:39][CH2:38]1

Participants

6

Reactant 5

HCID 6329MethylamineHCID 8452CyclopentanoneHCID 729302-Aminonicotinic acidHCID 5195414-Hydroxy-2-MethoxybenzaldehydeHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 11647733HCID 11647733, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 2-aminonicotinic acid, methylamine, 2-methoxy-4-hydroxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and cyclopentanone.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-bc76349230f94f4eb8c0881e5fe2cbc1
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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