4-Hydroxybenzaldehyde → HCID 67244226, compound

HRID 2422665Notes

Reaction equation

HRID 2422665 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:12]([NH2:14])[CH3:13].[OH:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1.O[CH:25]1[CH2:30][CH2:29][N:28]([C:31](OC(C)(C)C)=O)[CH2:27][CH2:26]1.[C:38]1(=O)[CH2:41]C[CH2:39]1>>[CH:31]1([N:28]2[CH2:27][CH2:26][CH:25]([O:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]4[N:14]([CH2:12][CH3:13])[C:4](=[O:6])[C:3]5[C:2](=[C:10]([CH3:11])[CH:9]=[CH:8][CH:7]=5)[N:1]=4)=[CH:18][CH:17]=3)[CH2:30][CH2:29]2)[CH2:41][CH2:38][CH2:39]1

Participants

6

Reactant 5

HCID 1264-HydroxybenzaldehydeHCID 6341EthylamineHCID 14496CyclobutanoneHCID 781012-Amino-3-methylbenzoic acidHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 67244226HCID 67244226, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 2-amino-3-methylbenzoic acid, ethylamine, 4-hydroxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and cyclobutanone.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-f70610003cbb4fe6b21937006375ebea
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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