HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → 2-(4-Methylpyridin-2-yl)-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | 2-Hydrazinyl-4-methylpyridine | HCID 12266739 | — |
| Reactant | Ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate | HCID 66726233 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Methylpyridin-2-yl)-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one | HCID 25074376 | — |
Reaction Steps
250 mg (1.19 mmol) of the compound from Example 3A, 122 mg (0.99 mmol) of the compound from Example 1A and 23 mg (99 μmol) camphor-10-sulfonic acid are dissolved in 5 ml anhydrous ethanol and the mixture is heated under reflux overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653111B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-4de7ebc70cd14a32b7277e3fac48bc1d |
| Source note | uspto-grants-2014_02 |