Methylamine → HCID 67244844, compound

HRID 2422679Notes

Reaction equation

HRID 2422679 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10]C)=O)=[CH:6][N:5]=[CH:4][C:3]=1[CH3:12].[CH3:13][NH2:14]>>[NH2:1][C:2]1[C:7]([C:8]([NH:14][CH3:13])=[O:10])=[CH:6][N:5]=[CH:4][C:3]=1[CH3:12]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 12037812HCID 12037812, compound

Product 1

HCID 67244844HCID 67244844, compoundYield 91%

Conditions

Temperature
100 °C

Procedure

Methyl 4-amino-5-methylnicotinate (100 mg, 0.60 mmol) and methylamine (2.0 M in MeOH, 2 mL) were mixed, and stirred under heat at 100° C. in a sealed tube for 24 hours. The solvent was evaporated off under reduced pressure, and the resulting residue was purified through silica gel column chromatography (chloroform/methanol=9/1) to obtain the intended compound (91 mg, 91%) as a yellow solid.

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. customthe resulting residue was purified through silica gel column chromatography (chloroform/methanol=9/1)

Sources & evidence

ORD record
ord-eca04269738d427cbe13f75221ff7c71
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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