反应详情

5-Bromo-3-nitropyridine-2-carboxamide (400 mg, 1.63 mmol), ammonium chloride (435 mg, 8.15 mmol) and iron powder (273 mg, 4.89 mmol) were suspended in methanol (6 mL) and water (3 mL), and stirred at 100° C. for 20 hours. After cooled to room temperature, this was filtered through Celite, and the Celite was washed with methanol. The mother liquid was concentrated, and the residue was dissolved in chloroform and washed with water. The organic layer was concentrated under reduced pressure to obtain the intended compound (246 mg, 70%).

1. filtrationthis was filtered through Celite
2. washthe Celite was washed with methanol
3. concentrationThe mother liquid was concentrated
4. dissolutionthe residue was dissolved in chloroform
5. washwashed with water
6. concentrationThe organic layer was concentrated under reduced pressure