反应详情

Lithium hydroxide monohydrate (16.68 g, 400 mmol) was added to a stirred solution of (1R)-1-[2-(3-methylphenyl)-2H-tetrazol-5-yl]ethyl acetate (46.6 g, 190 mmol) in tetrahydrofuran/water (1:1, 750 mL). After 3 hour reaction time the mixture was concentrated to half volume. Brine (100 mL) was added and the mixture was extracted with ethyl acetate (3×100 mL). The combined organic layer was dried over sodium sulfate, filtered and concentrated to give the title product (38.18 g, 99%).

1. customAfter 3 hour reaction time the mixture
2. concentrationwas concentrated to half volume
3. additionBrine (100 mL) was added
4. extractionthe mixture was extracted with ethyl acetate (3×100 mL)
5. dry with materialThe combined organic layer was dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated