反应详情

Batch 1: 7.5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 1.7 g (5.4 mmol) of the compound from Example 71. The mixture is stirred at RT, 5 ml dioxane are added and the mixture is stirred at RT for 16 h. The solid is filtered off and washed with 5 ml dioxane. The mixture is dried under a high vacuum for 16 h, 10 ml methanol are then added and the mixture is stirred at RT for 1 h. The solid is filtered off, washed with 4 ml methanol and dried under a high vacuum. 1.6 g of the title compound are obtained.

1. stirringthe mixture is stirred at RT for 16 h
2. filtrationThe solid is filtered off
3. washwashed with 5 ml dioxane
4. customThe mixture is dried under a high vacuum for 16 h
5. addition10 ml methanol are then added
6. stirringthe mixture is stirred at RT for 1 h
7. filtrationThe solid is filtered off
8. washwashed with 4 ml methanol
9. customdried under a high vacuum