Hydrochloric Acid → HCID 67453577, compound

HRID 242280Notes

Reaction equation

HRID 242280 reaction equation
[ClH:1].FC(F)(F)C(O)=O.[N:9]1([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCOCC1>[ClH:1].[N:9]1([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67455675HCID 67455675, compound

Product 1

HCID 67453577HCID 67453577, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 60 mg (0.1 mmol) of the compound from Example 73 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed twice with 0.5 ml dioxane each time and subsequently dried in vacuo.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed twice with 0.5 ml dioxane each time
  3. customsubsequently dried in vacuo

Sources & evidence

ORD record
ord-672fbdd2934249b39f32710cb3f99359
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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