HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N,N-Diethyl-5-(hydrazinecarbonyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 5-(diethylcarbamoyl)thiophene-2-carboxylate | HCID 52267985 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N,N-Diethyl-5-(hydrazinecarbonyl)thiophene-2-carboxamide | HCID 57688164 | 89% |
Reaction Steps
Methyl 5-(diethylcarbamoyl)thiophene-2-carboxylate (247 mg, 1.02 mmol) in ethanol (9 mL) was stirred with hydrazine monohydrate (495 mg, 10.2 mol) at 90° C. for 6 hours. After addition of water, the reaction solution was extracted with ethyl acetate and chloroform, and the extract was dried over anhydrous magnesium sulfate and concentrated to give the desired product (yield 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960425B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-582f3e1410a94ab49c769565f6493c61 |
| Source note | uspto-grants-2011_06 |