反应详情

Methyl 5-(diethylcarbamoyl)thiophene-2-carboxylate (247 mg, 1.02 mmol) in ethanol (9 mL) was stirred with hydrazine monohydrate (495 mg, 10.2 mol) at 90° C. for 6 hours. After addition of water, the reaction solution was extracted with ethyl acetate and chloroform, and the extract was dried over anhydrous magnesium sulfate and concentrated to give the desired product (yield 89%).

1. extractionthe reaction solution was extracted with ethyl acetate and chloroform
2. dry with materialthe extract was dried over anhydrous magnesium sulfate
3. concentrationconcentrated