Hydrazine hydrate (1:1) → HCID 67243107, compound

HRID 2422810Notes

Reaction equation

HRID 2422810 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1F.O.[NH2:15][NH2:16]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([F:12])[C:3]=1[NH:15][NH2:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27770141,2,3-trifluoro-5-(trifluoromethyl)benzene

Product 1

HCID 67243107HCID 67243107, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1,2,3-trifluoro-5-(trifluoromethyl)benzene (300 g, 1.5 mmol) and hydrazine monohydrate (300 g, 6.0 mmol) in ethanol (1200 ml) was heated at reflux overnight. The reaction mixture was concentrated in vacuo and the residue was re-crystallised from 2-propanol to give Preparation 21 (194 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe residue was re-crystallised from 2-propanol
  5. customto give

Sources & evidence

ORD record
ord-14170d3bd8f04cc4b91f89f721cb37a3
Source dataset
uspto-grants-2011_06
Patent number
US07960426B2

Reaction notes

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