反应详情

To a solution of lithium wire (2.08 g, 300 mmol) in dry tetrahydrofuran (150 ml) was added methyldiphenylsilyl chloride (15.8 ml, 75 mmol) and a catalytic amount of iodine. The reaction mixture was sonicated for 40 min and then stirred overnight at room temperature. The reaction mixture was cooled to −78° C. and 1,1-difluoroethylene (approx. 225 mmol) was passed through the mixture for 30 min. The mixture was stirred at −78° C. for 2 h and then warmed to room temperature.

1. customThe reaction mixture was sonicated for 40 min
2. temperatureThe reaction mixture was cooled to −78° C.
3. stirringThe mixture was stirred at −78° C. for 2 h
4. temperaturewarmed to room temperature