Hydrochloric Acid → 2-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

HRID 242285Notes

Reaction equation

HRID 242285 reaction equation
[ClH:1].[OH:2][CH:3]1[CH2:6][N:5]([C:7]2[N:12]=[CH:11][N:10]=[C:9]([N:13]3[C:17](=[O:18])[C:16]([N:19]4[CH:23]=[CH:22][N:21]=[N:20]4)=[CH:15][NH:14]3)[CH:8]=2)[CH2:4]1>O1CCOCC1>[ClH:1].[OH:2][CH:3]1[CH2:4][N:5]([C:7]2[N:12]=[CH:11][N:10]=[C:9]([N:13]3[C:17](=[O:18])[C:16]([N:19]4[CH:23]=[CH:22][N:21]=[N:20]4)=[CH:15][NH:14]3)[CH:8]=2)[CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 596036202-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 674573592-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3 ml of a 4 N solution of hydrogen chloride in dioxane are added to 105 mg (0.4 mmol) of the compound from Example 88 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed with tert-butyl methyl ether and dried under a high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed with tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-5b625ffd805f42dfa827721d44ea7031
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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