1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride → N-[(1R)-1-[4-(5-fluoro-2-methoxyphenyl)phenyl]ethyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-sulfonamide
반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:27][CH3:28])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C@H:14]([NH:16]S(C3C=C(C)OC=3C)(=O)=O)[CH3:15])=[CH:10][CH:9]=2)[CH:7]=1.[CH3:29][N:30]1[CH:34]=[C:33]([S:35](Cl)(=[O:37])=[O:36])[C:32]([C:39]([F:42])([F:41])[F:40])=[N:31]1.FC1C=CC(OC)=C(C2C=CC(C(N)C)=CC=2)C=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:27][CH3:28])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C@H:14]([NH:16][S:35]([C:33]3[C:32]([C:39]([F:42])([F:41])[F:40])=[N:31][N:30]([CH3:29])[CH:34]=3)(=[O:37])=[O:36])[CH3:15])=[CH:10][CH:9]=2)[CH:7]=1참가 물질
4
반응물 3
생성물 1
실험 절차
Prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) starting with 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride and 1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 7.40, 7.16 (a/b, 4H), 7.05-6.88 (m, 3H), 4.89 (m, 1H), 4.60 (t, 1H), 3.80 (s, 3H), 3.72 (s, 3H), 1.52 (d, 3H) ppm; MS (ESI) m/z: 480 [M+Na]+.
출처 및 근거
- ORD 기록
- ord-0e86f466d63b4212aab09cdb0407eb25
- 출처 데이터셋
- uspto-grants-2011_06
- 특허 번호
- US07960365B2
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