1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride → N-[(1R)-1-[4-(5-fluoro-2-methoxyphenyl)phenyl]ethyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-sulfonamide

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Reaction Steps

Prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) starting with 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride and 1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 7.40, 7.16 (a/b, 4H), 7.05-6.88 (m, 3H), 4.89 (m, 1H), 4.60 (t, 1H), 3.80 (s, 3H), 3.72 (s, 3H), 1.52 (d, 3H) ppm; MS (ESI) m/z: 480 [M+Na]+.

Provenance & Evidence