Hydrochloric Acid → HCID 67457566, compound

HRID 242286Notes

Reaction equation

HRID 242286 reaction equation
[ClH:1].[CH3:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([N:10]2[C:14](=[O:15])[C:13]([N:16]3[CH:20]=[CH:19][N:18]=[CH:17]3)=[CH:12][NH:11]2)[CH:4]=1>O1CCOCC1>[ClH:1].[CH3:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([N:10]2[C:14](=[O:15])[C:13]([N:16]3[CH:20]=[CH:19][N:18]=[CH:17]3)=[CH:12][NH:11]2)[CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59603644HCID 59603644, compound

Product 1

HCID 67457566HCID 67457566, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 200 mg (0.5 mmol) of the compound from Example 90 and the mixture is stirred at RT for 1 h. The solid is then filtered off, washed in each case once with dioxane and tert-butyl methyl ether and dried under a high vacuum.

Workup

  1. filtrationThe solid is then filtered off
  2. washwashed in each case once with dioxane and tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-20bb7e73a6964478b143a72a0cbc3d91
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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