1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride → 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonic-acid (5'-fluoro-2,2'-dimethoxy-biphenyl-4-ylmethyl)-amide

HRID 2422861Notes

Reaction equation

HRID 2422861 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:29][CH3:30])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH:15]S(C3C=CC(OC)=CC=3)(=O)=O)=[CH:10][C:9]=2[O:27][CH3:28])[CH:7]=1.[CH3:31][N:32]1[CH:36]=[C:35]([S:37](Cl)(=[O:39])=[O:38])[C:34]([C:41]([F:44])([F:43])[F:42])=[N:33]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:29][CH3:30])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH:15][S:37]([C:35]3[C:34]([C:41]([F:44])([F:43])[F:42])=[N:33][N:32]([CH3:31])[CH:36]=3)(=[O:39])=[O:38])=[CH:10][C:9]=2[O:27][CH3:28])[CH:7]=1

Participants

3

Reactant 2

HCID 27945611-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chlorideHCID 24768914HCID 24768914, compound

Product 1

HCID 247690771-Methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonic-acid (5'-fluoro-2,2'-dimethoxy-biphenyl-4-ylmethyl)-amide

Procedure

Prepared in a similar manner to N-(5′-fluoro-2,2′-dimethoxy-biphenyl-4ylmethyl)-4-methoxy-benzenesulfonamide (Example 6) using 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride instead of 4-methoxybenzene sulfonyl chloride. Title compound: MS (ESI) m/z: 474.0 [M+H]+.

Sources & evidence

ORD record
ord-03197f09b1f2478f93a3e8875b475822
Source dataset
uspto-grants-2011_06
Patent number
US07960365B2

Reaction notes

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