huagongshe.com
HRID2422875

反应详情

EQUATION

反应方程式

HRID 2422875 的结构方程式

REACTANTS

反应物

3
结构：Cc1nn(C(F)F)c(C)c1S(=O)(=O)Cl
HCID6485421

1-Difluoromethyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride

C6H7ClF2N2O2S

结构：COc1ccc(F)cc1-c1ccc([C@@H](C)NS(=O)(=O)c2cc(C)oc2C)cc1
HCID24768970

未命名化合物

结构：CC(N)c1ccc(-c2ccccc2OC(F)(F)F)cc1
HCID61032839

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nn(C(F)F)c(C)c1S(=O)(=O)N[C@H](C)c1ccc(-c2ccccc2OC(F)(F)F)cc1
HCID67244507

未命名化合物

PROCEDURE

实验过程

Prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) starting with 1-difluoromethyl-3,5-dimethylpyrazole-4-sulfonyl chloride and 1-(2′-trifluoromethoxy-biphenyl-4-yl)-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 7.43-7.11 (m, 8H), 6.99 (s, 1H), 4.86 (s, 1H), 4.58 (m, 1H), 2.45 (s, 3H), 2.30 (s, 3H), 1.54 (d, 3H), ppm; MS (ESI) m/z: 490 [M+H]+.