1-(difluoromethyl)-3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride → (r)-1-Difluoromethyl-3,5-dimethyl-1h-pyrazole-4-sulfonic acid [1-(2'-trifluoromethoxy-biphenyl-4-yl)-ethyl]-amide

Beteiligte Stoffe

Reaktionsschritte

Prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) starting with 1-difluoromethyl-3,5-dimethylpyrazole-4-sulfonyl chloride and 1-(2′-trifluoromethoxy-biphenyl-4-yl)-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 7.43-7.11 (m, 8H), 6.99 (s, 1H), 4.86 (s, 1H), 4.58 (m, 1H), 2.45 (s, 3H), 2.30 (s, 3H), 1.54 (d, 3H), ppm; MS (ESI) m/z: 490 [M+H]+.

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