Hydrochloric Acid → 2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

HRID 242288Notes

Reaction equation

HRID 242288 reaction equation
[ClH:1].[CH3:2][C:3]([CH3:24])([CH3:23])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16](=[O:17])[C:15]([N:18]3[CH:22]=[CH:21][N:20]=[CH:19]3)=[CH:14][NH:13]2)=[N:10][CH:11]=1>O1CCOCC1>[ClH:1].[CH3:2][C:3]([CH3:24])([CH3:23])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16](=[O:17])[C:15]([N:18]3[CH:22]=[CH:21][N:20]=[CH:19]3)=[CH:14][NH:13]2)=[N:10][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 596036952-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 674550292-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 200 mg (0.638 mmol) of the compound from Example 92 and the mixture is stirred at RT for 30 min. The solid is subsequently filtered off, washed once with dioxane and twice with tert-butyl methyl ether and subsequently dried under a high vacuum.

Workup

  1. filtrationThe solid is subsequently filtered off
  2. washwashed once with dioxane and twice with tert-butyl methyl ether
  3. customsubsequently dried under a high vacuum

Sources & evidence

ORD record
ord-3d1b64b840084b38993ba32069957ed6
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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