Thionyl Chloride → HCID 86628705, compound

HRID 2422929Notes

Reaction equation

HRID 2422929 reaction equation
[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:5][C:4]([S:7]([O:10][CH2:11][C:12](O)=[O:13])(=[O:9])=[O:8])=[CH:3][CH:2]=1.S(Cl)([Cl:23])=O>>[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:5][C:4]([S:7]([O:10][CH2:11][C:12]([Cl:23])=[O:13])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 86628704HCID 86628704, compound

Product 1

HCID 86628705HCID 86628705, compound

Procedure

A mixture of acid 17 (200 mg, 0.685 mmol) and thionyl chloride (1 ml) was heated at reflux for 1.5 h. The excess thionyl chloride was removed in vacuo and the residue dried under high vacuum at 50° C. for 1.5 h. The product acid chloride 18 was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 h
  3. customThe excess thionyl chloride was removed in vacuo
  4. customthe residue dried under high vacuum at 50° C. for 1.5 h
  5. customThe product acid chloride 18 was used without further purification

Sources & evidence

ORD record
ord-8a4a5640e8f64b03b2048aae9e605d92
Source dataset
uspto-grants-2011_06
Patent number
US07960434B2

Reaction notes

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