Hydrochloric Acid → HCID 136330930, compound

HRID 242293Notes

Reaction equation

HRID 242293 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]1[N:13]=[C:12]([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[O:11][N:10]=1.[ClH:32]>O1CCOCC1>[ClH:32].[CH3:8][C:9]1[N:13]=[C:12]([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[O:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136399885HCID 136399885, compound

Product 1

HCID 136330930HCID 136330930, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10 mg (0.02 mmol) of the compound from Example 177 are stirred with a 4 N solution of hydrogen chloride in dioxane at RT for 2 h. Thereafter, the solvent is decanted off and the solid is stirred in tert-butyl methyl ether three times in succession and the solvent is decanted off each time. The solid which remains is dried under a high vacuum.

Workup

  1. customThereafter, the solvent is decanted off
  2. customthe solvent is decanted off each time
  3. customThe solid which remains is dried under a high vacuum

Sources & evidence

ORD record
ord-82d3274b23c042ecaf7496da0477a9b3
Source dataset
uspto-grants-2014_02
Patent number
US08653111B2

Reaction notes

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