反应详情

This was obtained as a white solid from cinnamoyl chloride (1.1 g, 6.62 mmol) and ethyl 4-aminobenzoate (1.10 g, 6.62 mmol) in a similar manner as described for preparation of 42. The reaction mixture was stirred at room temperature overnight and the mixture was poured in HCl (aq, 2N, 20 ml). The product was extracted with DCM (2×20 ml), dried over Na2SO4 and the solvent removed under reduced pressure. The crude amide 41 was used in the next step without further purification.

1. extractionThe product was extracted with DCM (2×20 ml)
2. dry with materialdried over Na2SO4
3. customthe solvent removed under reduced pressure
4. customThe crude amide 41 was used in the next step without further purification