Hydrochloric Acid → HCID 178424366, compound

Participants

Reaction Conditions

Reaction Steps

To 150 g of o-toluidine (product of Tokyo Chemical Industry) was added 109 g of a 35 to 37% aqueous solution of hydrochloric acid (product of Wako Pure Chemical Industries) and, after heating to 85° C., 128 g of a 50% aqueous solution of cyanamide (product of Sigma-Aldrich Corp.) was added dropwise. After completion of the dropping of the aqueous cyanamide solution, a further 26.8-g portion of the aqueous hydrochloric acid was immediately added, and the mixture was stirred at 85° C. for 2 hours. The reaction mixture was cooled to room temperature and then neutralized with 236 g of a 50% aqueous solution of potassium hydroxide (product of Wako Pure Chemical Industries) to give 1-(o-tolyl)guanidine.

Provenance & Evidence