Hydrochloric Acid → HCID 178424366, compound
Reaction equation
[NH2:1][C:2]1[C:3]([CH3:8])=[CH:4][CH:5]=[CH:6][CH:7]=1.Cl.[N:10]#[C:11][NH2:12].[OH-].[K+]>>[C:3]1([CH3:8])[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:11]([NH2:12])=[NH:10]Participants
5
Conditions
- Temperature
- 85 °C
Procedure
To 150 g of o-toluidine (product of Tokyo Chemical Industry) was added 109 g of a 35 to 37% aqueous solution of hydrochloric acid (product of Wako Pure Chemical Industries) and, after heating to 85° C., 128 g of a 50% aqueous solution of cyanamide (product of Sigma-Aldrich Corp.) was added dropwise. After completion of the dropping of the aqueous cyanamide solution, a further 26.8-g portion of the aqueous hydrochloric acid was immediately added, and the mixture was stirred at 85° C. for 2 hours. The reaction mixture was cooled to room temperature and then neutralized with 236 g of a 50% aqueous solution of potassium hydroxide (product of Wako Pure Chemical Industries) to give 1-(o-tolyl)guanidine.
Workup
- temperatureThe reaction mixture was cooled to room temperature
Sources & evidence
- ORD record
- ord-d0faf04c55de40dd9760fe6a304d7c62
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07960459B2
Reaction notes
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