Hydrochloric Acid → N-(3-chlorophenyl)-1-(methylsulfonyl)-methanehydrazonoyl chloride

Temperature

0 °C

Part A. 3-Chloroaniline (5.00 g, 39.2 mmol) was added dropwise to an ice-cold 1N hydrochloric acid solution followed by the addition of 4 mL of 12M hydrochloric acid. To this solution was slowly added an ice-cold solution of sodium nitrite (3.00 g, 43.1 mmol) in 4 mL of water while maintaining the internal temperature to less than 5° C. This solution was stirred for 45 min at 0° C. during which time a precipitate formed. Glacial acetic acid (1 mL) was added and the precipitate dissolved. To this solution was added solid sodium acetate (approx. 2 g) to adjust the pH to 4 and then 10 mL ice cold acetone was added followed by an ice cold solution of 1-chloro-1-methanesulfonyl-propan-2-one in 10 mL acetone. The reaction was allowed to warm to ambient temperature and stirred for 14 h. A stream of nitrogen was passed over the solution to slightly reduce the solvent volume. The solid precipitate was collected by filtration, washed twice with water, and dried in vacuo at 40° C. to give 8.47 g (81%) of N-(3-chlorophenyl)-1-(methylsulfonyl)-methanehydrazonoyl chloride as a light orange solid.

1. temperaturewhile maintaining the internal temperature to less than 5° C
2. customformed
3. dissolutionthe precipitate dissolved
4. temperatureto warm to ambient temperature
5. stirringstirred for 14 h
6. filtrationThe solid precipitate was collected by filtration
7. washwashed twice with water
8. customdried in vacuo at 40° C.

ORD record

ord-8ccc997ab3704fb89fcdd4b63952bb2c

Source dataset

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07960411B2