Hydrochloric Acid → Dimethylaminoacetaldehyde hydrogen sulphite

HRID 2423011Notes

Reaction equation

HRID 2423011 reaction equation
C([O:3][CH:4](OCC)[CH2:5][N:6]([CH3:8])[CH3:7])C.Cl.[S:13](S([O-])=O)([O-:16])(=[O:15])=[O:14].[Na+].[Na+].C(O)C>O>[CH3:7][N:6]([CH2:5][CH:4]=[O:3])[CH3:8].[S:13]([O-:16])([OH:15])=[O:14]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 77163(2,2-Diethoxyethyl)dimethylamineHCID 656671Sodium Pyrosulfite

Product 1

HCID 86636908Dimethylaminoacetaldehyde hydrogen sulphite

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

40 g of dimethylaminoacetaldehyde diethylacetal are heated to 40° C. in a mixture of 48 g conc, hydrochloric acid and 20 ml of water for 3 h. Then a solution of 42.4 g sodium pyrosulphite in 72 ml of water (sodium hydrogen sulphite solution) is added dropwise and the mixture is stirred for 1 h. 200 ml of ethanol are added and then the mixture is stirred for 2 h at 0° C. The suspension is suction filtered, washed with 160 ml of ethanol and dried at 45° C. in vacuo.

Workup

  1. stirringthe mixture is stirred for 2 h at 0° C
  2. filtrationsuction filtered
  3. washwashed with 160 ml of ethanol
  4. customdried at 45° C. in vacuo

Sources & evidence

ORD record
ord-98eb7a6643144b04a0ff5402f9a625cc
Source dataset
uspto-grants-2011_06
Patent number
US07960546B2

Reaction notes

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