4-Chloroaniline → N-(Benzimidazol-2-yl)-4-chloroaniline

HRID 2423028Notes

Reaction equation

Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[CH:18][C:12]([Cl:11])=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 78124-Chloroaniline

HCID 785722-Chlorobenzimidazole

Product 1

HCID 923854N-(Benzimidazol-2-yl)-4-chloroaniline

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-chloroaniline by Procedure A. The product was isolated by filtration and recrystallisation to give the title compound as a hydrochloride salt (white solid, mp 238-240° C.). MS(ES+) m/z 244 ([M+1]+, 100).

Workup

customThe product was isolated by filtration and recrystallisation

Sources & evidence

ORD record: ord-2d1e7315dc5a47db839f4fc3cba28783
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960561B2

Reaction notes

Loading…