4-(Trifluoromethyl)aniline → N-[4-(Trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423031Notes

Reaction equation

HRID 2423031 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]([F:21])([F:20])[C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:17][C:16]1[CH:18]=[CH:19][C:13]([C:12]([F:11])([F:20])[F:21])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 15604320N-[4-(Trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (white solid, mp 199-200° C.). MS(ES+) m/z 278 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration and preparative LCMS

Sources & evidence

ORD record
ord-7241984eb3f449489a1675537fbcb3dc
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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