2-Chlorobenzimidazole → N-[4-(Trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine

HRID 2423033Notes

Reaction equation

HRID 2423033 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]([F:22])([F:21])[O:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:18][C:17]1[CH:19]=[CH:20][C:14]([O:13][C:12]([F:11])([F:21])[F:22])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 15604435N-[4-(Trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-(trifluoromethoxy)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 250-251° C.). MS(ES+) m/z 294 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-b22494bc54b649ff8d526a976a9013fc
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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